FOR 24/7 ACID RELIEF -
USE RABEPRAZOLE 40 MG + DOMPERIDONE 30 mg
FOR 24/7 ACID RELIEF USE
ALIRAB FORTE
RABEPRAZOLE 40 MG + DOMPERIDONE 30 MG
USES
RABEPRAZOLE 40 MG + DOMPERIDONE 30 MG is a combination of two
drugs: domperidone (prokinetic drug) and rabeprazole (proton pump inhibitor).
Domperidone is used to treat nausea and vomiting. Rabeprazole is used to treat
peptic ulcer. Additionally, it is used to treat gastric oesophageal reflux
disease (GERD) and Zollinger-Ellison syndrome.
How does RABEPRAZOLE
40 MG + DOMPERIDONE 30 MG better?
In
patients with GERD and moderate to severe esophageal acid exposure, a dose of
20 mg and 40 mg per day of Rabeprazole Sodium delayed-release tablets decreased
24-hour esophageal acid exposure. Current PPIs may not achieve desired outcomes
in some GERD patients due to limited duration of acid inhibition.
Once-daily
Rabeprazole-ER 40 mg demonstrated a significantly longer acid suppression time
over a 24-h period and superior control of nocturnal gastric acid.*
*Ref. January
2011Alimentary Pharmacology & Therapeutics 33(2):203-12
DOI:
10.1111/j.1365-2036.2010.04516.x
SourcePubMed
SPECIAL
INSTRUCTIONS FOR RABEPRAZOLE 40 MG
+ DOMPERIDONE 30 MG
Other dose‐finding studies yielded similar results.21, 22
All patients with duodenal ulcers experienced complete healing by the end of 6
weeks and reported marked symptom improvement using rabeprazole doses ranging
from 10 to 40 mg once daily.21, 22 All patients with gastric ulcers experienced
either complete healing or marked improvement at the end of 8 weeks of
rabeprazole therapy. 21, 22 No clinically significant adverse events were
reported. *
* 21 Mod Physician 1994;
14: 23 7 // 22# 1994; 14: 1 22.
In another USA multicentre
study, patients with duo‐denal ulcer were treated
for 4 weeks with once‐daily placebo (n = 33),
rabeprazole 20 mg (n = 34), or rabeprazole 40 mg (n = 33). Both doses of
rabeprazole were significantly superior to placebo in promoting ulcer healing.
Healing rates were 79% in the 20‐mg group and 91% in the 40‐mg group, compared with 39% for placebo.
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