Cefuroxime and Clavulanic Acid
A combination of cefuroxime and ß -lactamase inhibitor
(Clavulanic acid) for the treatment of various bacterial infections.
CEFUROXIME :
Bactericidal action due to inhibition of cell-wall synthesis.
Clavulanic Acid :
Enzyme inhibitor that enhances the antibacterial activity
Why is this
medication prescribed ?
Cefuroxime is used to treat certain infections caused by
bacteria, such as bronchitis (infection of the airway tubes leading to the
lungs); gonorrhea (a sexually transmitted disease); Lyme disease (an infection
that may develop after a person is bitten by a tick); and infections of the
skin, ears, sinuses, throat, tonsils,, and urinary tract. Cefuroxime is in a
class of medications called cephalosporin antibiotics. It works by stopping the
growth of bacteria.
Antibiotics such as cefuroxime will not work for colds, flu,
or other viral infections. Using antibiotics when they are not needed increases
your risk of getting an infection later that resists antibiotic treatment.
How should this
medicine be used?
Cefuroxime comes as a tablet and a suspension (liquid) to
take by mouth. It is usually taken every 12 hours for 5-10 days, depending on
the condition being treated. To treat gonorrhea, cefuroxime is taken as a
single dose, and to treat Lyme disease, cefuroxime is taken every 12 hours for
20 days. Take the suspension with food; the tablet may be taken with or without
food . Take cefuroxime at around the same times every day. Follow the
directions on your prescription label carefully, and ask your doctor or pharmacist
to explain any part you do not understand. Take cefuroxime exactly as directed.
Do not take more or less of it or take it more often than prescribed by your
doctor.
Different cefuroxime products are absorbed by the body in
different ways and cannot be substituted for one another. If you need to switch
from one cefuroxime product to another, your doctor may need to adjust your
dose.
Shake the suspension well before each use to mix the
medication evenly.
The tablets should be swallowed whole. Because the crushed
tablet has a strong bitter taste, the tablet should not be crushed. Children
who cannot swallow the tablet whole should take the liquid instead.
You should begin to feel better during the first few days of
treatment with cefuroxime. If your symptoms do not improve or get worse, call
your doctor.
Take cefuroxime until you finish the prescription, even if
you feel better. If you stop taking cefuroxime too soon or skip doses, your
infection may not be completely treated, and the bacteria may become resistant
to antibiotics.
Other uses for this
medicine
Cefuroxime is also sometimes used to treat pneumonia. Talk
to your doctor about the risks of using this medication for your condition.
This medication may be prescribed for other uses; ask your
doctor or pharmacist for more information.
What special
precautions should I follow?
Before taking cefuroxime,
tell your doctor and pharmacist if you are allergic to
cefuroxime.
tell your doctor and pharmacist what prescription and
nonprescription medications, vitamins, nutritional supplements, and herbal
products you are taking or plan to take. Your doctor may need to change the
doses of your medications or monitor you carefully for side effects.
if you are taking antacids that contain magnesium or
aluminum, take them at least 1 hour before or 2 hours after cefuroxime.
tell your doctor if you have or have ever had
gastrointestinal disease (GI; affecting the stomach or intestines), especially
colitis (condition that causes swelling in the lining of the colon [large
intestine]), or kidney or liver disease.
you should know that cefuroxime decreases the effectiveness
of some oral contraceptives ('birth control pills). You will need to use
another form of birth control while taking this medication. Talk to your doctor
about other ways to prevent pregnancy while you are taking this medication.
tell your doctor if you are pregnant, plan to become
pregnant, or are breast-feeding. If you become pregnant while taking
cefuroxime, call your doctor.
if you have phenylketonuria (PKU, an inherited condition in
which a special diet must be followed to prevent mental retardation), you should
know that cefuroxime suspension is sweetened with aspartame that forms
phenylalanine.
What special dietary
instructions should I follow?
Unless your doctor tells you otherwise, continue your normal
diet.
What should I do if I
forget a dose?
Take the missed dose as soon as you remember it. However, if
it is almost time for the next dose, skip the missed dose and continue your
regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can
this medication cause?
Cefuroxime may cause side effects. Tell your doctor if any
of these symptoms are severe or do not go away:
· nausea
· vomiting
· diarrhea
Cefuroxime may cause other side effects. Call your doctor if
you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor
may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse
Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone
(1-800-332-1088).
What should I know
about storage and disposal of this medication?
Keep this medication in the container it came in, tightly
closed, and out of reach of children. Store the tablets at room temperature and
away from excess heat and moisture (not in the bathroom). Keep liquid medicine
in the refrigerator, tightly closed, and dispose of any unused medication after
10 days.
Symptoms of overdose may include:
· Seizures
What other
information should I know?
Keep all appointments with your doctor and the laboratory.
Your doctor may order certain lab tests to check your body's response to
cefuroxime.
Do not let anyone else take your medication. Your prescription
is probably not refillable.
It is important for you to keep a written list of all of the
prescription and nonprescription (over-the-counter) medicines you are taking,
as well as any products such as vitamins, minerals, or other dietary supplements.
You should bring this list with you each time you visit a doctor or if you are
admitted to a hospital. It is also important information to carry with you in
case of emergencies.
Brand names
CEFXER 500
CEFXER CV
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