THEOFRESH PLUS (NAC) – A POWERFUL MUCOLYTIC
N-acetyl
cysteine (NAC) is used by the body to build antioxidants.
Antioxidants are vitamins, minerals, and other nutrients that protect and
repair cells from damage.
You can get NAC as a supplement or a prescription drug.
Why do people take
NAC?
As a prescription drug, doctors use NAC to treat acetaminophen overdose.
It may also help break up mucus in people with some lung diseases,
like chronic bronchitis.
As a supplement, some people use NAC to try to protect the liver.
There's evidence it can help prevent kidney or neurologic damage caused by
some drugs.
N-acetylcysteine
(NAC) is the supplement form of the amino acid cysteine.
Proponents claim that taking N-acetylcysteine supplements can protect against a
plethora of health concerns, including respiratory diseases, liver disease,
psychiatric disorders, diabetes, certain cancers, and chemical dependency.
Health Benefits
In complementary and alternative medicine (CAM),
N-acetylcysteine is believed to help a wide range of medical conditions.
Because N-acetylcysteine can increase the production of glutathione, some practitioners
have posited that it not only prevents conditions like cancer and heart disease
by maintaining the integrity of cells, but also support the treatment of
certain diseases.
Proponents contend that
N-acetylcysteine has the potential to prevent or treat an almost encyclopedic
range of health problems, including:
- Allergic rhinitis (hay fever)
- Alzheimer's disease
- Bipolar disorder
- Bronchitis
- Carbon dioxide poisoning
- Chronic kidney disease
- Chronic obstructive pulmonary disorder
(COPD)
- Cirrhosis
- Cocaine dependence
- Colorectal cancer
- Conjunctivitis
- Cystic fibrosis
- Heart disease
- Hepatitis
- Hypercholesterolemia (high cholesterol)
- HIV
- Infertility
- Lou Gehrig's disease
- Lung cancer
- Lupus
- Polycystic ovary syndrome (PCOS)
- Post-traumatic distress syndrome (PTSD)
- Preterm labor or miscarriage
- Schizophrenia
- Unstable angina
- Upper respiratory infections
The expansive nature of
these claims borders on far-fetched. Even those claims for which there is at
least some related clinical research typically fall short, either because the
studies are small or the evidence doesn't support the often over-reaching
conclusions.
With that being said,
there have been some positive findings that warrant serious scientific
consideration. Here is a look at some of the research investigating the
benefits of N-acetylcysteine supplements.
Mechanism of action
A
number of possible mechanisms for the mucolytic activity of acetylcysteine have
been proposed. Acetylcysteine's sulfhydryl groups may hydrolize disulfide bonds
within mucin, breaking down the oligomers, and making the mucin less viscous.11,16 Acetylcysteine
has also been shown to reduce mucin secretion in rat models.11 It is
an antioxidant in its own right but is also deacetylated to cysteine, which
participates in the synthesis of the antioxidant glutathione.11 The
antioxidant activity may also alter intracellular redox reactions, decreasing
phosphorylation of EGFR and MAPK, which decrease transcription of the gene
MUC5AC which produces mucin.11
In
the case of acetaminophen overdoses, a portion of the drug is metabolized by
CYP2E1 to form the potentially toxic metabolite N-acetyl-p-benzoquinone imine
(NAPQI).16 The
amount of NAPQI produced in an overdose saturates and depletes glutathione
stores.16 The
free NAPQI promiscuously binds to proteins in hepatocytes, leading to cellular
necrosis.16 Acetylcysteine
can directly conjugate NAPQI or provide cysteine for glutathione production and
NAPQI conjugation.16
A Word From Alisier
Only minute amounts of N-acetylcysteine are found in
food. Still, cysteine deficiency is not very common, although vegetarians
and vegans with a low intake of cysteine-rich plant foods may be at risk.
Those working to make sure they have adequate levels
of NAC can consider supplementation, but should also be mindful about consuming
these foods, which are excellent food sources of the amino acid: poultry, eggs,
dairy, red peppers, garlic, onions, broccoli, Brussels sprouts, oats, and wheat
germ.
Our
THEOFRESH PLUS known for its ability to replenish levels of the antioxidant
glutathione, it also regulates the important brain neurotransmitter glutamate.
Additionally, THEOFRESH PLUS helps the body’s detoxification system. These
functions make NAC supplements a viable treatment option for multiple health
problems.
For
more information contact :
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